Predictive bioinformatic identification of minor receptor group human rhinoviruses
نویسندگان
چکیده
منابع مشابه
Major and minor receptor group human rhinoviruses penetrate from endosomes by different mechanisms.
Intercellular adhesion molecule 1 and the low-density lipoprotein receptor are used for cell entry by major and minor receptor group human rhinoviruses (HRVs), respectively. Whereas minor-group viruses, exemplified by HRV2, transfer their genomic RNA to the cytoplasm through a pore in the endosomal membrane (E. Prchla, C. Plank, E. Wagner, D. Blaas, and R. Fuchs, J. Cell Biol. 131:111-123, 1995...
متن کاملReceptor priming of major group human rhinoviruses for uncoating and entry at mild low-pH environments.
Receptor priming of low-pH-triggered virus entry has been described for an enveloped virus (15). Here we show with major group human rhinoviruses (HRV) and its intercellular adhesion molecule-1 receptor that nonenveloped viruses follow this novel cell entry principle. In vitro the receptor primed HRV for efficient uncoating at mild low pH (5.5 to 6.0). Agents preventing endosomal acidification ...
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Major- and minor-group human rhinoviruses (HRV) enter their host by binding to the cell surface molecules ICAM-1 and LDL-R, respectively, which are present on both macrophages and epithelial cells. Although epithelial cells are the primary site of productive HRV infection, previous studies have implicated macrophages in establishing the cytokine dysregulation that occurs during rhinovirus-induc...
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Human–murine chimeras of ICAM-1 identify amino acid residues critical for rhinovirus and antibody binding. virus binding to receptor: studies with rhinovirus, intercellular adhesion molecule-1 (ICAM-1) and surface plasmon resonance. Formation of rhinovirus soluble ICAM-1 complexes and conformational changes in the virion. The pathway of rhinovirus disruption by soluble intercellular adhesion mo...
متن کاملEpidemiology of Human Rhinoviruses
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2009
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2009.07.015